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Ageing In Human Cells Successfully Reversed In The Lab

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WEB Notes: Amazing stuff right here. They are a long way from making this happen, but this was an interesting read. Not only to understand what they are trying to accomplish, but to understand how cells work…

Our Father’s handy work is all around us and in us. How anyone could understand the sciences and just looking at nature and not believe in our Father is beyond me. Ensure you nudge those individuals in the right direction when you are able.

Source: The Conversation

The ability to reverse ageing is something many people would hope to see in their lifetime. This is still a long way from reality, but in our latest experiment, we have reversed the ageing of human cells, which could provide the basis for future anti-degeneration drugs.

Ageing can be viewed as the progressive decline in bodily function and is linked with most of the common chronic diseases that humans suffer from, such as cancer, diabetes and dementia. There are many reasons why our cells and tissues stop functioning, but a new focus in the biology of ageing is the accumulation of “senescent” cells in the tissues and organs.

Senescent cells are older deteriorated cells that do not function as they should, but also compromise the function of cells around them. Removal of these old dysfunctional cells has been shown to improve many features of ageing in animals such as the delayed onset of cataracts.

We still don’t fully understand why cells become senescent as we age, but damage to DNA, exposure to inflammation and damage to the protective molecules at the end of the chromosomes – the telomeres – have all been suggested.

More recently, people have suggested that one driver of senescence may be loss of our ability to turn genes on and off at the right time and in the right place.

One Gene, Many Messages

As we age, we lose our ability to control how our genes are regulated. Each cell in the body contains all the information needed for life, but not all genes are switched on in all tissues or under all conditions. This is one of the ways that a heart cell is different from a kidney cell, despite the fact they contain the same genes.

When a gene is activated by signals from inside or outside the cell, it makes a molecular message (called an RNA) that contains all the information needed to make whatever that gene makes. We now know that over 95% of our genes can actually make several different types of messages, depending on the needs of the cell.

A good way to think about this is to consider each gene as a recipe. You could make either a vanilla sponge, or a chocolate cake, depending on whether you include the chocolate. Our genes can work like this. The decision as to which type of message is produced at any given time is made by a group of about 300 proteins called “splicing factors”.

As we age, the amount of splicing factors we are able to make declines. This means that aged cells are less able to switch genes on and off to respond to changes in their environment. We and others have shown that the levels of these important regulators decline in blood samples from elderly humans, and also in isolated human senescent cells of different tissue types.

Rejuvenating Old Cells

We have been looking for ways to turn the splicing factors back on. In our new work, we showed that by treating old cells with a chemical that releases small amounts of hydrogen sulphide, we were able to increase levels of some splicing factors, and to rejuvenate old human cells.

Hydrogen sulphide is a molecule that is found naturally in our bodies and has been shown to improve several features of age-related disease in animals. But it can be toxic in large amounts, so we needed to find a way to deliver it directly to the part of the cell where it is needed.

By using a “molecular postcode” we have been able to deliver the molecule directly to the mitochondria, the structures that produce energy in cells, where we think it acts, allowing us to use tiny doses, which are less likely to cause side effects.

We are hopeful that in using molecular tools such as this, we will be able to eventually remove senescent cells in living people, which may allow us to target multiple age-related diseases at once. This is some way in the future yet, but it’s an exciting start.

Source: Ageing in human cells successfully reversed in the lab



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6 Comments

  1. To reverse the toxins of man that battle the longevity of the flesh is an admirable achievement. If accomplished? To think the goal to surpass what the Father has placed as the biblical cap/line is another! And that will always be the goal for most! Man-made immortality! Whether it be within the flesh is worldly doubtful! So as is already pursuant. They will try to continue research to accomplish the transfer of your memory as an upload to the mechanical brain/body should it ever be made possible!!?? NOT!! The Unbeliever will never stop to achieve their own form of wishful eternity! And the Father will NOT allow it’s achievement past His will! That you can be assured! All things will be fulfilled long before it’s possibility. Amen! Hallelujah! 😁👍👊

    • “man-made immortality”—perhaps our Father banks on that, that with His plan of salvation, there will be many that will decide to be with Him in the eternity (rather than join Death). ie: since man seems to really want immortality, that is.

      • True! But it will only be achieved through salvation and transition from the flesh to the spiritual body. Death of the flesh. And of course the acceptance of the Word. Christ our Lord and eternity granted! Many would like to bypass it all and find immortality without! (Man-made). That is and was my main point! It will not happen! Period… Those who choose His plan of salvation SHOULD not perish (Is conditional) KJV John 3:16. NIV- SHALL not perish ( unconditional). I shall go with the KJV. I am not a once saved always saved Christian. One can fall from God’s grace if not careful of their actions which the Word clearly declares. There are conditions! Immortality definitely has a multiplicity of conditions that many don’t care to comply too. What a shame! I always give thanks for the thought of the Millenium! A Time outside the flesh to hear and learn the truth without worldly influence! Merciful grace! If one refuses that! They deserve what’s coming in my opinion! And that is because God’s judgement will be just that from His throne at 1000.1!

        Who would ever want that… Blows my mind!!! 😳💥

        • Yes, we understand eternal now in the flesh. I think i focus more on winning and crushing evil that goes against our Father and His family and creation. We each are different.

  2. Driving for God.

    August 14, 2018 at 12:41 PM

    Rejuvenating old cells is nothing God hasn’t done from the book of Genesis with Abraham to healing the lame and restoring life to dead cells in the four Gospels. Science keeps on showing the proof of God’s intervention in man’s shortened longevity. The truth in the Bible never is wrong.

  3. long life is a blessing from God, but still in the flesh, we get only that day (used to be almost 1000 flesh years). Not only did many not want those blessings, so they don’t get them, but we don’t farm or eat correctly—as well as overt poisoning of land/sea and air by not considering negative outcomes over the almighty dollar. Use a bad egg in a meringue, and see how well that does. Inflammation is usually caused by assaults on the body, whichever area is being attacked by the poison/substance. If our systems are fighting these negatives all the time, they have very little nutrients left to augment proper functioning and cellular renewal. I know, hard to prove.

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